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Development and Validation of Differential Spectrophotometric method for Determination of Pantoprazole in Tablet Dosage Form
karuppa samy
ABSTRACT: A simple, rapid and sensitive difference spectrophotometric method was used for the determination of Pantoprazole in pharmaceutical dosage forms. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their ...
Arabian Journal of Chemistry
A modified high-performance liquid chromatographic method for the analysis of pantoprazole sodium in pharmaceutical dosage forms using lansoprazole as internal standard
2016 •
Safwan Ashour
New Spectrophotometric Method for Determination of Pantoprazole in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent
2012 •
Safwan Ashour
Chemical Industry & Chemical Engineering Quarterly
Sensitive and selective spectrophotometric determination of pantoprazole sodium in pharmaceuticals using permanganate
2010 •
Okram Zenita
E-Journal of Chemistry
Determination of Pantoprazole Sodium and Lansoprazole in Individual Tablet Dosage Forms by RP-HPLC Using Single Mobile Phase
2009 •
RAMANJANEYA REDDY
A simple, sensitive and precise high performance liquid chromatographic method for the analysis of pantoprazole sodium and lansoprazole has been developed, validated and used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated an isocratically on a C18column [Inertsil C18, 5μ, 150 mm x 4.6 mm] utilizing a mobile phase consisting of acetonitrile: phosphate buffer (60:40, v/v, pH 7.0) at a flow rate of 1.0 mL/min with UV detection at 230 nm. The retention time of pantoprazole sodium and lansoprazole was found to be 2.017 min and 2.538. The procedure was validated for linearity (Correlation coefficient=0.999). The study showed that reversed-phase liquid chromatography is sensitive and selective for the determination of pantoprazole sodium and lansoprazole using single mobile phase.
STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR THE ESTIMATION OF PANTOPRAZOLE SODIUM IN TABLET DOSAGE FORM
Faraat Ali
The aim of the present study is to develop a simple, sensitive, rapid, accurate and precise reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Pantoprazole sodium in bulk and pharmaceutical dosage forms. Analytical method was developed by using Waters X-Bridge Shield C-18 (4.6×150 mm, 5µm) column; mobile phase consisting of ACN and ammonium bicarbonate phosphate buffer at pH 9.0; the flow rate of 1.0 ml/min and detection wavelength 214nm and eluted at 4.766 min. The method was found to be simple, accurate, economical, Precise and reproducible. There was no interference of any degradants and excipient in the determination of drugs in marketed formulation. So the method can be successfully applied for routine analysis.
Sensitive liquid chromatography–tandem mass spectrometry method for the determination of pantoprazole sodium in human urine
Ashish Dwivedi
A sensitive and selective liquid chromatographic–tandem mass spectrometric (LC–MS– MS) method was developed to determine pantoprazole sodium (PNT) in human urine. After solid-phase extraction with SPE cartridge, the urine sample was analysed on a C 18 column (symmetry 3.5 lm; 75 mm · 4.6 mm i.d) interfaced with a triple quadrupole tandem mass spectrometer. Positive electrospray ionization was employed as the ionization source. The mobile phase consisted of acetonitrile–water (90:10, v/v). The method was linear over a concentration range of 1– 100 ng mL À1. The lower limit of quantitation was 1 ng mL À1. The intra-day and inter-day relative standard deviation across three validation runs over the entire concentration range was <10.5%. The accuracy determined at three concentrations (8.0, 50.0 and 85.0 ng mL À1 PNT) was within ±1.25% in terms of relative errors.
Orbital: The Electronic Journal of Chemistry
Stability indicating RP-HPLC method for simultaneous determination of pantoprazole sodium and itopride hydrochloride in bulk and capsule
2010 •
Krishna Gupta
A stability indicating reversed-phase HPLC method has been developed and subsequently validated for simultaneous estimation of pantoprazole present as pantoprazole sodium sesquihydrate (PSS), and itopride hydrochloride from their combination product. The proposed RP-HPLC method utilizes a Phenomenex® C18, 5 µm, 250 mm X 4.6 mm i.d. column, mobile phase consisting of phosphate buffer and acetonitrile in the proportion of 55:45 (v/v) with apparent pH adjusted to 5.0, and UV detection at 289.0 nm using a UV detector. PAN, ITH and their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were analyzed by the proposed method. The described method was linear over a range of 4-20 µg/mL for PAN and 15-75 µg/mL for ITH. The mean recoveries were 100.02 and 99.88 for PAN and ITH, respectively. Chromatographic peak purity data of PAN and ITH indicated no co-eluting peaks with the main peaks of drugs which demonstrate...
July - September 2010 80 Journal of Pharmacy and Chemistry • Vol.4 • Issue.3 *Address for correspondence:Development and validation of bio-analytical method for quantification of pantoprazole in human plasma using LC-MS/MS
RAMR S
Open Access Macedonian Journal of Medical Sciences
A New Solid-Phase Extraction Method for Determination of Pantoprazole in Human Plasma Using High-Performance Liquid Chromatography
2019 •
Dragica Zendelovska
